Biophysical characterization of α-glucan nanoparticles encapsulating feruloylated soy glycerides (FSG)

Biotechnol Rep (Amst). 2023 Nov 2:40:e00817. doi: 10.1016/j.btre.2023.e00817. eCollection 2023 Dec.

Abstract

Water insoluble α-glucans that were enzymatically synthesized using glucansucrase that was cloned from Leuconostoc mesenteroides NRRL B-1118 were previously shown to form nanoparticles via high pressure homogenization. These α-glucan nanoparticles were previously shown capable of encapsulating a small hydrophobic molecule. This work demonstrates that the same α-glucan can be formed into nanoparticles that encapsulate feruloylated soy glycerides from modified soybean oil, a product of interest to the cosmetic and skin care industries because of the UV absorbance and antioxidant properties of the feruloyl moiety. It is demonstrated that the feruloylated soy glyceride/α-glucan nanoparticles have distinct size, zeta potential and thermal profiles from that of nanoparticles made from α-glucan alone or feruloylated soy glyceride alone. Thermal analysis also demonstrates the release of feruloylated soy glycerides from the α-glucan nanoparticles.

Keywords: Encapsulation; Feruloyl soy glycerides; Nanoparticles; α-glucan.