Risk factors for recurrent cerebral amyloid angiopathy-related intracerebral hemorrhage

Xinglei Jia; Menghan Bo; Hong Zhao; Jia Xu; Luqian Pan; Zhengyu Lu

doi:10.3389/fneur.2023.1265693

Risk factors for recurrent cerebral amyloid angiopathy-related intracerebral hemorrhage

Front Neurol. 2023 Nov 7:14:1265693. doi: 10.3389/fneur.2023.1265693. eCollection 2023.

Authors

Xinglei Jia^#¹, Menghan Bo^#¹, Hong Zhao², Jia Xu¹, Luqian Pan³, Zhengyu Lu¹

Affiliations

¹ VIP Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Teaching Affairs Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
³ Department of Geriatrics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

^# Contributed equally.

Abstract

Background: Cerebral amyloid angiopathy (CAA) is the most common cause of lobar intracerebral hemorrhage (ICH) in the elderly, and its multifocal and recurrent nature leads to high rates of disability and mortality. Therefore, this study aimed to summarize the evidence regarding the recurrence rate and risk factors for CAA-related ICH (CAA-ICH).

Methods: We performed a systematic literature search of all English studies published in PubMed, Embase, Web of Science, Cochrane Library, Scopus, and CINAHL from inception to June 10, 2023. Studies reporting CAA-ICH recurrence rates and risk factors for CAA-ICH recurrence were included. We calculated pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) using a random/fixed-effects model based on the I² assessment of heterogeneity between studies. Publication bias was assessed using Egger's test.

Results: Thirty studies were included in the final analysis. Meta-analysis showed that the recurrence rate of CAA-ICH was 23% (95% CI: 18-28%, I² = 96.7%). The risk factors significantly associated with CAA-ICH recurrence were: previous ICH (OR = 2.03; 95% CI: 1.50-2.75; I² = 36.8%; N = 8), baseline ICH volume (OR = 1.01; 95% CI: 1-1.02; I² = 0%; N = 4), subarachnoid hemorrhage (cSAH) (OR = 3.05; 95% CI: 1.86-4.99; I² = 0%; N = 3), the presence of cortical superficial siderosis (cSS) (OR = 2.04; 95% CI: 1.46-2.83; I² = 0%; N = 5), disseminated cSS (OR = 3.21; 95% CI: 2.25-4.58; I² = 16.0%; N = 6), and centrum semiovale-perivascular spaces (CSO-PVS) severity (OR = 1.67; 95% CI: 1.14-2.45; I² = 0%; N = 4).

Conclusion: CAA-ICH has a high recurrence rate. cSAH, cSS (especially if disseminated), and CSO-PVS were significant markers for recurrent CAA-ICH. The onset of ICH in patients with CAA is usually repeated several times, and recurrence is partly related to the index ICH volume. Identifying clinical and neuroimaging predictors of CAA-ICH recurrence is of great significance for evaluating outcomes and improving the prognosis of patients with CAA-ICH.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=400240, identifier [CRD42023400240].

Keywords: cerebral amyloid angiopathy; cerebral small vessel disease; cortical superficial siderosis; intracerebral hemorrhage; recurrence.

Publication types

Systematic Review

Grants and funding

The author (s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 81973803 and 82274431), Shanghai Healthcare Research Special Project (Grant No. 202240039), and the Science and Technology Innovation Cultivation Program of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (Grant Nos. YD202210 and YD202219).