Multisite Mpox Infection and Viral Dynamics Among Persons With HIV in Metro Atlanta

Gregory L Damhorst; A Wendy Fujita; Eric Fitts; Brittany Szabo; Heather B Bowers; Courtney Sabino; Alaa Ahmed; Ethan Wang; Anne Piantadosi; Kaleb McLendon; Julie Sullivan; Morgan Greenleaf; Divine McCaslin; Melody Palmore; Albert M Anderson; Bruce Aldred; Clifford Gunthel; Greg S Martin; Jonathan A Colasanti; Wilbur A Lam; Leda Bassit; Anuradha Rao; Anandi N Sheth; Boghuma K Titanji

doi:10.1093/infdis/jiad530

Multisite Mpox Infection and Viral Dynamics Among Persons With HIV in Metro Atlanta

J Infect Dis. 2024 Mar 26;229(Supplement_2):S213-S218. doi: 10.1093/infdis/jiad530.

Authors

Gregory L Damhorst^{1

2

3}, A Wendy Fujita^{1

2}, Eric Fitts^{3

4}, Brittany Szabo^{1

2}, Heather B Bowers^{3

5

6}, Courtney Sabino^{3

5

6}, Alaa Ahmed⁷, Ethan Wang⁴, Anne Piantadosi^{1

4}, Kaleb McLendon⁴, Julie Sullivan^{3

5}, Morgan Greenleaf³, Divine McCaslin², Melody Palmore^{1

2}, Albert M Anderson^{1

2}, Bruce Aldred^{1

2}, Clifford Gunthel^{1

2}, Greg S Martin^{3

8}, Jonathan A Colasanti^{1

2}, Wilbur A Lam^{3

5

9

10}, Leda Bassit^{3

5

6}, Anuradha Rao^{3

5}, Anandi N Sheth^{1

2}, Boghuma K Titanji^{1

2}

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Emory University.
² Ponce de Leon Center, Grady Health System.
³ Atlanta Center for Microsystems-Engineered Point-of-Care Technologies.
⁴ Department of Pathology and Laboratory Medicine.
⁵ Department of Pediatrics, School of Medicine.
⁶ Laboratory of Biochemical Pharmacology.
⁷ Emory Integrated Genomics Core.
⁸ Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University.
⁹ Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta.
¹⁰ Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia.

PMID: 38019187
PMCID: PMC10965212 (available on 2024-11-29)
DOI: 10.1093/infdis/jiad530

Abstract

The 2022 mpox outbreak primarily involved sexual transmission among men who have sex with men and disproportionately affected persons with human immunodeficiency virus (HIV). We examined viral dynamics and clinical features in a cohort evaluated for mpox infection at a comprehensive HIV clinic in Atlanta, Georgia. Viral DNA was found in 8 oropharyngeal and 5 anorectal specimens among 10 mpox cases confirmed by lesion swab polymerase chain reaction. Within-participant anatomic site of lowest cycle threshold (Ct) value varied, and lower Ct values were found in oropharyngeal and anorectal swabs when corresponding symptoms were present. This provides insight into mpox infection across multiple anatomic sites among people with HIV.

Keywords: HIV; anorectal; mpox; oropharyngeal; viral load.

MeSH terms

Ambulatory Care Facilities
HIV Infections*
Homosexuality, Male
Humans
Male
Mpox (monkeypox)*
Sexual and Gender Minorities*

Abstract

MeSH terms

Grants and funding