A high sensitivity optical fiber twist sensor based on Suspend Core Fiber Sagnac Interference (SCFSI) is proposed and experimentally demonstrated. By filling the air hole of the Suspend Core Fiber (SCF) with alcohol, the twist sensitivity of the twist sensor is greatly improved to 8.37 nm/°. Moreover, the valid angle measurement range of the sensor can be expanded by utilizing the combination of intensity demodulation and wavelength demodulation. The sensor not only has high twist angle sensitivity but also exhibits a capability of temperature calibration. Since the wavelength shifts of the interference fringes of Mach-Zehnder Interferometer (MZI) formed in the suspend core of SCF appears insensitive to twist angle, the parasitic interference formed by MZI can be used for temperature calibration. Due to compact structure, easy fabrication and low temperature cross sensitivity, the proposed sensor has a great potential for structural health monitoring, such as buildings, towers, bridges, and many other infrastructures.