Comparative protective efficacy of a newly generated live recombinant thermostable highly attenuated vaccine rK148/GVII-F using a single regimen against lethal NDV GVII.1.1

Avian Pathol. 2024 Feb;53(1):14-32. doi: 10.1080/03079457.2023.2263395. Epub 2023 Dec 19.

Abstract

A thermostable, safe, and effective NDV GVII recombinant vaccine was generated.Fusion gene replacement with GVII did not affect GI K148/08 virus thermostability.Strain rK148/GVII-F provided adequate protection against a lethal NDV challenge.Oropharyngeal shedding was significantly reduced on post-challenge days 5 and 7.

Keywords: Newcastle disease virus; genotype VII; protective efficacy; recombinant vaccine; thermostability; viral shedding.

MeSH terms

  • Animals
  • Antibodies, Viral
  • Chickens
  • Genotype
  • Newcastle Disease*
  • Newcastle disease virus / genetics
  • Poultry Diseases* / prevention & control
  • Vaccines, Attenuated
  • Vaccines, Synthetic
  • Viral Vaccines*

Substances

  • Vaccines, Attenuated
  • Viral Vaccines
  • Vaccines, Synthetic
  • Antibodies, Viral