A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles

Thoraya A Farghaly; Ghada S Masaret; Sayed M Riyadh; Marwa F Harras

doi:10.2174/0113895575277122231108095511

A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles

Mini Rev Med Chem. 2023 Nov 24. doi: 10.2174/0113895575277122231108095511. Online ahead of print.

Authors

Thoraya A Farghaly¹, Ghada S Masaret¹, Sayed M Riyadh², Marwa F Harras³

Affiliations

¹ Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukaramah 21514, Saudi Arabia.
² Chemistry Department, Faculty of Science, University of Cairo, Giza 12613, Egypt.
³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.

PMID: 38008942
DOI: 10.2174/0113895575277122231108095511

Abstract

Out of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs or non-nucleosides. Many synthetic techniques have been produced by scientists around the world as a result of their wide-ranging biological function. In this review, we have tried to summarize new synthetic methods produced by diverse research groups as well as provide a comprehensive description of the function of [1,2,4] and [1,2,3]-triazole derivatives as antiviral agents. Antiviral triazole compounds have been shown to target a wide variety of molecular proteins. In addition, several strains of viruses, including the human immunodeficiency virus, SARS virus, hepatitis B and C viruses, influenza virus, Hantavirus, and herpes virus, were discovered to be susceptible to triazole derivatives. This review article covered the reports for antiviral activity of both 1,2,3- and 1,2,4-triazole moieties up to 2022.

Keywords: 1; 2; 3-triazoles; 4-triazoles; Antiviral activity; COVID-19; HCV; heterocycles.