4 Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, 70, Lien-Hai Road, Kaohsiung, 80424, Taiwan; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, Taiwan; Institute of Precision Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan; International Ph.D. Program for Science, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan. Electronic address: hwu@faculty.nsysu.edu.tw.