Small Animal Multisubject PET/CT Workflow

Alexia Kirby; Adam J Shuhendler

doi:10.1007/978-1-0716-3499-8_11

Small Animal Multisubject PET/CT Workflow

Methods Mol Biol. 2024:2729:185-193. doi: 10.1007/978-1-0716-3499-8_11.

Authors

Alexia Kirby^{1

2}, Adam J Shuhendler^{3

4}

Affiliations

¹ Department of Biology, University of Ottawa, Ottawa, ON, Canada.
² University of Ottawa Heart Institute, Ottawa, ON, Canada.
³ University of Ottawa Heart Institute, Ottawa, ON, Canada. Adam.Shuhendler@uottawa.ca.
⁴ Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada. Adam.Shuhendler@uottawa.ca.

PMID: 38006497
DOI: 10.1007/978-1-0716-3499-8_11

Abstract

Positron emission tomography (PET) is a highly sensitive molecular imaging technique that uses radioactive tracers to map molecular and metabolic processes in living animals. PET can be performed as a stand-alone modality but is often combined with CT to provide for objective anatomical localization of PET signals in a multimodality approach. In order to outline the general approach to evaluating four mice simultaneously by dynamic PET imaging, the use of the aldehyde-targeted radiotracer [¹⁸F]NA₃BF₃ in mouse models of hepatotoxicity will be described. Indeed the production of aldehydes is upregulated in a wide range of disease and injury, making them a suitable biomarker for PET imaging of numerous pathologies.

Keywords: Aldehydes; In-vivo imaging; PET-CT; Positron emission tomography; hepatotoxicity.

MeSH terms

Animals
Mice
Multimodal Imaging
Positron Emission Tomography Computed Tomography* / methods
Positron-Emission Tomography*
Radioactive Tracers
Workflow

Substances

Radioactive Tracers