Rapid Radiolabeling for Peptide Radiotracers

Xiaowei Ma; Zhen Cheng

doi:10.1007/978-1-0716-3499-8_7

Rapid Radiolabeling for Peptide Radiotracers

Methods Mol Biol. 2024:2729:103-115. doi: 10.1007/978-1-0716-3499-8_7.

Authors

Xiaowei Ma¹, Zhen Cheng^{2

3}

Affiliations

¹ Department of Nuclear Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
² State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. chengzhen@shanghaitech.edu.cn.
³ Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, China. chengzhen@shanghaitech.edu.cn.

PMID: 38006493
DOI: 10.1007/978-1-0716-3499-8_7

Abstract

Peptide-based radiopharmaceuticals (PRPs) have been developed and introduced into research and clinic diagnostic imaging and targeted radionuclide therapy for more than two decades. In order to efficiently prepare PRPs, some rapid radiolabeling methods have been demonstrated. This chapter presents six common approaches for PRPs radiolabeling with metallic radioisotopes and Fluorine-18.

Keywords: Fluorine-18; Metallic radioisotopes; Peptide; Peptide-based radiopharmaceuticals; Radiochemistry; Radiolabeling.

MeSH terms

Fluorine Radioisotopes*
Peptides
Positron-Emission Tomography* / methods
Radiopharmaceuticals

Substances

Fluorine Radioisotopes
Radiopharmaceuticals
Peptides