Scandium Radioisotopes-Toward New Targets and Imaging Modalities

Molecules. 2023 Nov 19;28(22):7668. doi: 10.3390/molecules28227668.

Abstract

The concept of theranostics uses radioisotopes of the same or chemically similar elements to label biological ligands in a way that allows the use of diagnostic and therapeutic radiation for a combined diagnosis and treatment regimen. For scandium, radioisotopes -43 and -44 can be used as diagnostic markers, while radioisotope scandium-47 can be used in the same configuration for targeted therapy. This work presents the latest achievements in the production and processing of radioisotopes and briefly characterizes solutions aimed at increasing the availability of these radioisotopes for research and clinical practice.

Keywords: radiochemical separation; radiolabeling; radiopharmaceuticals; scandium radioisotopes; theranostics.

Publication types

  • Review

MeSH terms

  • Precision Medicine
  • Radioisotopes / chemistry
  • Radioisotopes / therapeutic use
  • Radiopharmaceuticals* / chemistry
  • Radiopharmaceuticals* / therapeutic use
  • Scandium* / chemistry

Substances

  • Radiopharmaceuticals
  • Scandium
  • Radioisotopes

Grants and funding

This research received no external funding.