Associations of Adipocytokines with The Development of Cardiovascular Events in Young People

Alena D Khudiakova; Yana V Polonskaya; Victoria S Shramko; Lilia V Shcherbakova; Evgeniia V Garbuzova; Elena V Kashtanova; Yulia I Ragino

doi:10.3390/jpm13111582

Associations of Adipocytokines with The Development of Cardiovascular Events in Young People

J Pers Med. 2023 Nov 7;13(11):1582. doi: 10.3390/jpm13111582.

Authors

Alena D Khudiakova¹, Yana V Polonskaya¹, Victoria S Shramko¹, Lilia V Shcherbakova¹, Evgeniia V Garbuzova¹, Elena V Kashtanova¹, Yulia I Ragino¹

Affiliation

¹ Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC&G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia.

Abstract

The research was aimed to study the associations of adipocytokines with the risk of cardiovascular events and to determine the threshold values of adipocytes for the prognosis of cardiovascular events in a young population.

Materials and methods: The study is an epidemiological cohort study. The analysis included 1240 people aged 25-44 years. The endpoint was combined and included: death from cardiovascular disease, myocardial infarction, probable myocardial infarction, acute cerebrovascular accident, hospitalization for cardiovascular disease, and revascularization. Adipocytokines were determined with a MILLIPLEX panel.

Results: In the examined population, 1.7% of cases of cardiovascular events were detected during cohort observation, of which 28.6% were fatal events. In men, cardiovascular endpoints were recorded 4.3 times more often than in women (17 (81%) vs. 4 (19%), p = 0.003). In individuals with cardiovascular events, arterial hypertension (2.6 times), diabetes mellitus (8.6 times), and overweight/obesity (1.5 times) were more often recorded compared to individuals without cardiovascular events. For tumor necrosis factor-alpha (TNFa), the threshold value was 2.5 pg/mL, with sensitivity assessment (Se) at 85.7% and specificity (Sp) at 83.3%. For amylin, the threshold value was 10.5 pg/mL, with Se at 73.7% and Sp at 67.0%. For pancreatic polypeptide (PP), the threshold value was 43.7 pg/mL, with Se at 85.7% and Sp at 56.7%.

Conclusion: A method for assessing the risk of cardiovascular events in young people includes determining the levels of amylin, PP, and TNFa in blood serum. The cut-off points for predicting cardiovascular events were levels of amylin above 10.5 pg/mL, PP above 43.7 pg/mL, or a decrease in TNFa below 3.8 pg/mL.

Keywords: adipocytokines; cardiovascular events; endpoints; young people.

Grants and funding

The work was supported by budget theme “Formation of cohorts of children, adolescents, and young people to study the mechanisms and features of the human life cycle in the Russian population” (No. 122031700115-7), with the support of the grant of the Russian Science Foundation No. 21-15-00022.