Preimplantation Genetic Testing for Genetic Diseases: Limits and Review of Current Literature

Genes (Basel). 2023 Nov 17;14(11):2095. doi: 10.3390/genes14112095.

Abstract

Preimplantation genetic testing (PGT) has emerged as a revolutionary technique in the field of reproductive medicine, allowing for the selection and transfer of healthy embryos, thus reducing the risk of transmitting genetic diseases. However, despite remarkable advancements, the implementation of PGT faces a series of limitations and challenges that require careful consideration. This review aims to foster a comprehensive reflection on the constraints of preimplantation genetic diagnosis, encouraging a broader discussion about its utility and implications. The objective is to inform and guide medical professionals, patients, and society overall in the conscious and responsible adoption of this innovative technology, taking into account its potential benefits and the ethical and practical challenges that it presents.

Keywords: biopsy; limits; pgt-a; pgt-m; pgt-sr; preimplantation genetic testing.

Publication types

  • Review

MeSH terms

  • Female
  • Genetic Testing* / methods
  • Humans
  • Pregnancy
  • Preimplantation Diagnosis* / methods

Grants and funding

This work was funded by the European Union—NextGenerationEU—NRRP M6C2—Investment: 2.1, “Enhancement and strengthening of biomedical research within the NSH”, (grant number PNRR-MR1-2022-12376108).