SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants

Fan Shen; Chun Liang; Cui-Xian Yang; Ying Lu; An-Qi Li; Ying Duan; Mi Zhang; Ren-Rong Tian; Xing-Qi Dong; Yong-Tang Zheng; Wei Pang

doi:10.1016/j.virs.2023.11.007

SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants

Virol Sin. 2024 Feb;39(1):173-176. doi: 10.1016/j.virs.2023.11.007. Epub 2023 Nov 23.

Authors

Fan Shen¹, Chun Liang¹, Cui-Xian Yang², Ying Lu¹, An-Qi Li¹, Ying Duan¹, Mi Zhang², Ren-Rong Tian³, Xing-Qi Dong², Yong-Tang Zheng⁴, Wei Pang⁵

Affiliations

¹ Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
² Yunnan Provincial Infectious Disease Hospital, Kunming, 650399, China.
³ Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
⁴ Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: zhengyt@mail.kiz.ac.cn.
⁵ Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China. Electronic address: pangw@mail.kiz.ac.cn.

Abstract

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Inactivated vaccine breakthrough infection with ancestral variants induced nearly undetectable nAbs against XBB variants.
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Inactivated vaccine breakthrough infection with Omicron BA.1 or BA.5 evoked very weak nAbs against XBB variants.
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BA.5 infection induced higher nAbs against XBB variants than BA.1 infection.

Publication types

Letter

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
Breakthrough Infections
COVID-19 Vaccines
COVID-19* / prevention & control
Humans
SARS-CoV-2 / genetics
Vaccination

Substances

COVID-19 Vaccines
Antibodies, Viral
Antibodies, Neutralizing

Supplementary concepts

COVID-19 breakthrough infections