Hepatocyte nuclear factor 4 a (HNF4α): A perspective in cancer

Ningxin Qu; Ting Luan; Naiquan Liu; Chenhui Kong; Le Xu; Hong Yu; Ye Kang; Ye Han

doi:10.1016/j.biopha.2023.115923

Hepatocyte nuclear factor 4 a (HNF4α): A perspective in cancer

Biomed Pharmacother. 2023 Dec 31:169:115923. doi: 10.1016/j.biopha.2023.115923. Epub 2023 Nov 24.

Authors

Ningxin Qu¹, Ting Luan², Naiquan Liu³, Chenhui Kong¹, Le Xu¹, Hong Yu¹, Ye Kang⁴, Ye Han⁵

Affiliations

¹ The Breast Oncology Dept., Shengjing Hospital of China Medical University, Shenyang, China.
² Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
³ The Nephrological Dept., Shengjing Hospital of China Medical University, Shenyang, China.
⁴ The Pathology Dept, Shengjing Hospital of China Medical University, Shenyang, China.
⁵ The Breast Oncology Dept., Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: hany1@sj-hospital.org.

PMID: 38000355
DOI: 10.1016/j.biopha.2023.115923

Abstract

HNF4α, a transcription factor, plays a vital role in regulating functional genes and biological processes. Its alternative splicing leads to various transcript variants encoding different isoforms. The spotlight has shifted towards the extensive discussion on tumors interplayed withHNF4α abnormalities. Aberrant HNF4α expression has emerged as sentinel markers of epigenetic shifts, casting reverberations upon downstream target genes and intricate signaling pathways, most notably with cancer. This review provides a comprehensive overview of HNF4α's involvement in tumor progression and metastasis, elucidating its role and underlying mechanisms.

Keywords: DNA methylation; Epigenetics; HNF4α; Histone; Tumor.

Publication types

Review

MeSH terms

Alternative Splicing / genetics
Hepatocyte Nuclear Factor 4* / genetics
Hepatocyte Nuclear Factor 4* / metabolism
Humans
Neoplasms* / genetics
Protein Isoforms / genetics

Substances

Hepatocyte Nuclear Factor 4
Protein Isoforms