Identification of 3'-terminal 2'-O-methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC

Xu Guo; Hongyuan Guo; Kuan-Chen Lu; Xin Yan; Jiehao Chen; Yanting Wei; Jiayi Han; Wu Sun; Huanhuan Hu; Yuanyuan Su; Lingyan Shen; Yujing Zhang; Kai Yin; Chen-Yu Zhang; Zheng Fu

doi:10.1002/ctm2.1454

Identification of 3'-terminal 2'-O-methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC

Clin Transl Med. 2023 Nov;13(11):e1454. doi: 10.1002/ctm2.1454.

Authors

Xu Guo^{1

2}, Hongyuan Guo¹, Kuan-Chen Lu¹, Xin Yan³, Jiehao Chen¹, Yanting Wei⁴, Jiayi Han⁵, Wu Sun⁶, Huanhuan Hu¹, Yuanyuan Su¹, Lingyan Shen¹, Yujing Zhang^{1

7}, Kai Yin^{1

8}, Chen-Yu Zhang^{1

7

9

10}, Zheng Fu^{1

9}

Affiliations

¹ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
² Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
³ Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
⁵ The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
⁶ Department of Oncology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
⁷ Institute of Artificial Intelligence Biomedicine, Nanjing University, Nanjing, Jiangsu, China.
⁸ Department of General Surgery, Taixing Hospital Affiliated to Yangzhou University, Taixing, Jiangsu, China.
⁹ Research Unit of Extracellular RNA, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.
¹⁰ Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Carcinoma, Non-Small-Cell Lung* / diagnosis
Carcinoma, Non-Small-Cell Lung* / genetics
Humans
Lung Neoplasms* / diagnosis
Lung Neoplasms* / genetics
MicroRNAs* / genetics

Substances

MicroRNAs
Biomarkers

Publication types

MeSH terms

Substances

Grants and funding