Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis

Alex Mayer; Grace McLaughlin; Amy Gladfelter; N Louise Glass; Alexander Mela; Marcus Roper

doi:10.1007/978-3-031-37936-9_9

Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis

Results Probl Cell Differ. 2024:71:159-183. doi: 10.1007/978-3-031-37936-9_9.

Authors

Alex Mayer¹, Grace McLaughlin^{2

3}, Amy Gladfelter², N Louise Glass⁴, Alexander Mela⁴, Marcus Roper^{5

6}

Affiliations

¹ Department of Mathematics, University of California Los Angeles, Los Angeles, CA, USA.
² Department of Cell Biology, Duke University, Durham, NC, USA.
³ Department of Biology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
⁴ Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, USA.
⁵ Department of Mathematics, University of California Los Angeles, Los Angeles, CA, USA. mroper@math.ucla.edu.
⁶ Department of Computational Medicine, University of California Los Angeles, Los Angeles, CA, USA. mroper@math.ucla.edu.

PMID: 37996678
DOI: 10.1007/978-3-031-37936-9_9

Abstract

Fast growth and prodigious cellular outputs make fungi powerful tools in biotechnology. Recent modeling work has exposed efficiency gains associated with dividing the labor of transcription over multiple nuclei, and experimental innovations are opening new windows on the capacities and adaptations that allow nuclei to behave autonomously or in coordination while sharing a single, common cytoplasm. Although the motivation of our review is to motivate and connect recent work toward a greater understanding of fungal factories, we use the analogy of the assembly line as an organizing idea for studying coordinated gene expression, generally.

Keywords: Compartmentalization; Division of labor; Filamentous fungi; Gene expression; Mathematical model; Noise; Nuclear autonomy; Nuclear coordination; Syncytia.

Publication types

Review

MeSH terms

Cell Nucleus*
Cytoplasm / metabolism
Fungal Proteins* / metabolism
Giant Cells

Substances

Fungal Proteins