Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions

Huijeong Jeong; Vijay Mohan K Namboodiri; Min Whan Jung; Mark L Andermann

doi:10.1016/j.cub.2023.10.073

Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions

Curr Biol. 2023 Dec 4;33(23):5185-5198.e4. doi: 10.1016/j.cub.2023.10.073. Epub 2023 Nov 22.

Authors

Huijeong Jeong¹, Vijay Mohan K Namboodiri², Min Whan Jung³, Mark L Andermann⁴

Affiliations

¹ Department of Neurology, University of California, San Francisco, 1651 4th Street, San Francisco, CA 94158, USA; Center for Synaptic Brain Dysfunctions, Institute for Basic Science, 291 Daehak-ro, Daejeon 34141, Republic of Korea; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon 34141, Republic of Korea.
² Department of Neurology, University of California, San Francisco, 1651 4th Street, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, 1651 4th Street, San Francisco, CA 94158, USA; Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, University of California, San Francisco, 1651 4th Street, San Francisco, CA 94158, USA. Electronic address: vijaymohan.knamboodiri@ucsf.edu.
³ Center for Synaptic Brain Dysfunctions, Institute for Basic Science, 291 Daehak-ro, Daejeon 34141, Republic of Korea; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon 34141, Republic of Korea. Electronic address: mwjung@kaist.ac.kr.
⁴ Division of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address: manderma@bidmc.harvard.edu.

PMID: 37995696
PMCID: PMC10842729 (available on 2024-12-04)
DOI: 10.1016/j.cub.2023.10.073

Abstract

Cortical neurons activated during recent experiences often reactivate with dorsal hippocampal CA1 ripples during subsequent rest. Less is known about cortical interactions with intermediate hippocampal CA1, whose connectivity, functions, and ripple events differ from dorsal CA1. We identified three clusters of putative excitatory neurons in mouse visual cortex that are preferentially excited together with either dorsal or intermediate CA1 ripples or suppressed before both ripples. Neurons in each cluster were evenly distributed across primary and higher visual cortices and co-active even in the absence of ripples. These ensembles exhibited similar visual responses but different coupling to thalamus and pupil-indexed arousal. We observed a consistent activity sequence preceding and predicting ripples: (1) suppression of ripple-suppressed cortical neurons, (2) thalamic silence, and (3) activation of intermediate CA1-ripple-activated cortical neurons. We propose that coordinated dynamics of these ensembles relay visual experiences to distinct hippocampal subregions for incorporation into different cognitive maps.

Keywords: Neuropixels; cortical ensemble; dorsal CA1; hippocampus; intermediate CA1; offline state; ripple; thalamus; visual cortex.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arousal
Hippocampus* / physiology
Mice
Neurons* / physiology
Parietal Lobe
Thalamus

Abstract

Publication types

MeSH terms

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