Topology-regulated nanocatalysts for ferroptosis-mediated cancer phototherapy

Guobo Chen; Liping Gu; Yongtian Liu; Jun Du; Qingwen Qi; Qing Miao; Jingxiang Wu; Yuqing Miao; Yuhao Li

doi:10.1016/j.jcis.2023.11.119

Topology-regulated nanocatalysts for ferroptosis-mediated cancer phototherapy

J Colloid Interface Sci. 2024 Feb 15:656:320-331. doi: 10.1016/j.jcis.2023.11.119. Epub 2023 Nov 20.

Authors

Guobo Chen¹, Liping Gu², Yongtian Liu², Jun Du², Qingwen Qi², Qing Miao³, Jingxiang Wu⁴, Yuqing Miao², Yuhao Li⁵

Affiliations

¹ Department of Anesthesiology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; School of Materials and Chemistry, Institute of Bismuth, Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, University of Shanghai for Science and Technology, Shanghai 200093, China.
² School of Materials and Chemistry, Institute of Bismuth, Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, University of Shanghai for Science and Technology, Shanghai 200093, China.
³ Department of Anesthesiology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address: miaoqmz@163.com.
⁴ Department of Anesthesiology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address: wjx1132@163.com.
⁵ School of Materials and Chemistry, Institute of Bismuth, Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: yhli@usst.edu.cn.

PMID: 37995402
DOI: 10.1016/j.jcis.2023.11.119

Abstract

Ferroptosis-mediated tumor treatment is constrained by the absence of single-component, activatable multifunctional inducers. Given this, a topological synthesis strategy is employed to develop an efficient bismuth-based semiconductor nano-photocatalyst (Bi₂O₃:S) for tumor ferroptosis therapy. Photo-excited electrons can participate in the reduction reaction to produce harmful reactive oxygen species (ROS) when exposed to near-infrared light. Meanwhile, photo-excited holes can contribute to the oxidation reaction to utilize extra glutathione (GSH) in tumors. In the acidic tumor microenvironment, bismuth ions generated from Bi₂O₃:S may further cooperate with GSH to amplify oxidative stress damage and achieve biodegradation. Both promote ferroptosis by downregulating glutathione peroxidase 4 (GPX4) expression. Besides, sulfur doping optimizes its near-infrared light-induced photothermal conversion efficiency, benefiting its therapeutic effect. Thus, bismuth ions and holes synergistically drive photo-activable ferroptosis in this nanoplatform, opening up new avenues for tumor therapy.

Keywords: Bismuth; Ferroptosis; Hole therapy; Photocatalytic therapy; Topological synthesis.

MeSH terms

Bismuth
Cell Line, Tumor
Ferroptosis*
Glutathione
Humans
Ions
Neoplasms* / therapy
Photochemotherapy*
Phototherapy
Reactive Oxygen Species
Tumor Microenvironment

Substances

Bismuth
Glutathione
Reactive Oxygen Species
Ions