Circular RNA Translation in Cardiovascular Diseases

Lijun Wang; Xinxin Cui; Fei Jiang; Yuxue Hu; Wensi Wan; Guoping Li; Yanjuan Lin; Junjie Xiao

doi:10.2174/1389202924666230911121358

Circular RNA Translation in Cardiovascular Diseases

Curr Genomics. 2023 Oct 27;24(2):66-71. doi: 10.2174/1389202924666230911121358.

Authors

Lijun Wang^{1

2}, Xinxin Cui^{1

2}, Fei Jiang^{3

4}, Yuxue Hu^{1

2}, Wensi Wan^{1

2}, Guoping Li⁵, Yanjuan Lin^{3

4}, Junjie Xiao^{1

2}

Affiliations

¹ Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, 226011, China.
² Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, 200444, China.
³ Department of Nursing, Union Hospital, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
⁴ Fujian Provincial Special Reserve Talents Laboratory, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
⁵ Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

Abstract

Circular RNAs (circRNAs) are a class of endogenous functional RNA generated by back-splicing. Recently, circRNAs have been found to have certain coding potential. Proteins/peptides translated from circRNAs play essential roles in various diseases. Here, we briefly summarize the basic knowledge and technologies that are usually applied to study circRNA translation. Then, we focus on the research progress of circRNA translation in cardiovascular diseases and discuss the perspective and future direction of translatable circRNA study in cardiovascular diseases.

Keywords: CircRNAs; RNA m6A; cardiovascular diseases; internal ribosome entry sites (IRES); proteins; ribosomal scanning.

Publication types

Editorial