Development of a Clinicopathological-Radiomics Model for Predicting Progression and Recurrence in Meningioma Patients

Mengna He; Xiaolan Wang; Chencui Huang; Xiting Peng; Ning Li; Feng Li; Hao Dong; Zhengyang Wang; Lingli Zhao; Fengping Wu; Minming Zhang; Xiaojun Guan; Xiaojun Xu

doi:10.1016/j.acra.2023.10.059

Development of a Clinicopathological-Radiomics Model for Predicting Progression and Recurrence in Meningioma Patients

Acad Radiol. 2023 Nov 22:S1076-6332(23)00614-1. doi: 10.1016/j.acra.2023.10.059. Online ahead of print.

Authors

Mengna He¹, Xiaolan Wang², Chencui Huang³, Xiting Peng², Ning Li⁴, Feng Li³, Hao Dong³, Zhengyang Wang², Lingli Zhao², Fengping Wu², Minming Zhang⁵, Xiaojun Guan², Xiaojun Xu²

Affiliations

¹ Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China (M.H., X.W., X.P., Z.W., L.Z., F.W., M.Z., X.G., X.X.); Department of Radiology, Shaoxing No. 2 Hospital Medical Community General Hospital, Shaoxing, China (M.H.).
² Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China (M.H., X.W., X.P., Z.W., L.Z., F.W., M.Z., X.G., X.X.).
³ Department of Research Collaboration, R&D Center, Beijing Deepwise & League of PHD Technology Co, Ltd, Beijing, China (C.H., F.L., H.D.).
⁴ Department of Radiology, Fuyang District First People's Hospital, Hangzhou, China (N.L.).
⁵ Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China (M.H., X.W., X.P., Z.W., L.Z., F.W., M.Z., X.G., X.X.). Electronic address: zhangminming@zju.edu.cn.

PMID: 37993304
DOI: 10.1016/j.acra.2023.10.059

Abstract

Rationale and objectives: Tumor progression and recurrence（P/R）after surgical resection are common in meningioma patients and can indicate poor prognosis. This study aimed to investigate the values of clinicopathological information and preoperative magnetic resonance imaging (MRI) radiomics in predicting P/R and progression-free survival (PFS) in meningioma patients.

Methods and materials: A total of 169 patients with pathologically confirmed meningioma were included in this study, 54 of whom experienced P/R. Clinicopathological information, including age, gender, Simpson grading, World Health Organization (WHO) grading, Ki-67 index, and radiotherapy history, as well as preoperative traditional radiographic findings and radiomics features for each MRI modality (T1-weighted, T2-weighted, and enhanced T1-weighted images) were initially extracted. After feature selection, the optimal performance was estimated among the models established using different feature sets. Finally, Cox survival analysis was further used to predict PFS.

Results: Ki-67 index, Simpson grading, WHO grading, and radiotherapy history were found to be independent predictors for P/R in the multivariate regression analysis. This clinicopathological model had an area under the curve (AUC) of 0.865 and 0.817 in the training and testing sets, respectively. The performance of the combined radiomics model reached 0.85 and 0.84, respectively. A clinicopathological-radiomics model was then established, which significantly improved the prediction of meningioma P/R (AUC = 0.93 and 0.88, respectively). Finally, the risk ratio was estimated for each selected feature, and the C-index of 0.749 was obtained.

Conclusion: Radiomics signatures of preoperative MRI have the ability to predict meningioma at the risk of P/R. By integrating clinicopathological information, the best performance was achieved.

Keywords: Ki-67 index; Magnetic resonance imaging; Meningioma; Progression-free survival; Progression/recurrence; Radiomics; Simpson grading; WHO grading.