Cp2Fe-Mediated Electrochemical Synthesis of Phosphorylated Oxindoles and Indolo[2,1- a]isoquinolin-6(5 H)-ones

Xiaocong Zhou; Jian Wang; Yirui Shen; Dumei Ma; Yufen Zhao; Ju Wu

doi:10.1021/acs.joc.3c02017

Cp₂Fe-Mediated Electrochemical Synthesis of Phosphorylated Oxindoles and Indolo[2,1- a]isoquinolin-6(5 H)-ones

J Org Chem. 2023 Dec 15;88(24):17521-17526. doi: 10.1021/acs.joc.3c02017. Epub 2023 Nov 22.

Authors

Xiaocong Zhou¹, Jian Wang¹, Yirui Shen^{2

3}, Dumei Ma⁴, Yufen Zhao¹, Ju Wu¹

Affiliations

¹ Institute of Drug Discovery Technology, Ningbo University, Zhejiang 315211, China.
² School of Materials and Chemical Engineering, Ningbo University of Technology, Ningbo 315211, Zhejiang China.
³ Zhejiang Institute of Tianjin University, Ningbo, Zhejiang 315201, China.
⁴ Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Zhejiang 315211, China.

PMID: 37990818
DOI: 10.1021/acs.joc.3c02017

Abstract

An efficient and environmentally friendly electrochemical synthesis of phosphorylated oxindoles and indolo[2,1-a]isoquinolin-6(5H)-ones mediated by readily available Cp₂Fe has been developed, which illustrated a broad substrate scope and diverse functional group compatibility. This protocol featured an external oxidant-free process and was at room temperature, which was proposed to be driven by the anodic oxidation of Cp₂Fe.