[Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children]

Zhongguo Dang Dai Er Ke Za Zhi. 2023 Nov 15;25(11):1150-1155. doi: 10.7499/j.issn.1008-8830.2305025.
[Article in Chinese]

Abstract
in English, Chinese

Objectives: To investigate the expression and significance of jumonji domain-containing protein 2B (JMJD2B) and hypoxia-inducible factor-1α (HIF-1α) in non-Hodgkin's lymphoma (NHL) tissues in children.

Methods: Immunohistochemistry was used to detect the expression of JMJD2B and HIF-1α in lymph node tissue specimens from 46 children with NHL (observation group) and 24 children with reactive hyperplasia (control group). The relationship between JMJD2B and HIF-1α expression with clinicopathological characteristics and prognosis in children with NHL, as well as the correlation between JMJD2B and HIF-1α expression in NHL tissues, were analyzed.

Results: The positive expression rates of JMJD2B (87% vs 21%) and HIF-1α (83% vs 42%) in the observation group were higher than those in the control group (P<0.05). The expression of JMJD2B and HIF-1α was correlated with serum lactate dehydrogenase levels and the risk of international prognostic index in children with NHL (P<0.05). The expression of JMJD2B was positively correlated with the HIF-1α expression in children with NHL (rs=0.333, P=0.024).

Conclusions: JMJD2B and HIF-1α are upregulated in children with NHL, and they may play a synergistic role in the development of pediatric NHL. JMJD2B can serve as a novel indicator for auxiliary diagnosis, evaluation of the severity, treatment guidance, and prognosis assessment in pediatric NHL.

目的: 探讨含jumonji结构域的蛋白2B（jumonji domain-containing protein 2B, JMJD2B）和缺氧诱导因子1α（hypoxia inducible factor-1α, HIF-lα）在儿童非霍奇金淋巴瘤（non-Hodgkin's lymphoma, NHL）组织中的表达和意义。方法: 应用免疫组化检测46例NHL儿童（观察组）和24例反应性增生儿童（对照组）淋巴结组织标本中JMJD2B和HIF-1α的表达，分析JMJD2B和HIF-1α与NHL患儿临床病理特征和预后的关系，以及在NHL组织中JMJD2B和HIF-1α表达的相关性。结果: 观察组JMJD2B（87% vs 21%）和HIF-1α（83% vs 42%）表达阳性率均高于对照组（P<0.05）。JMJD2B和HIF-1α表达与NHL患儿血清乳酸脱氢酶水平和国际预后指数危险度相关（P<0.05）。JMJD2B与HIF-1α在NHL患儿组织中的表达呈正相关（rs=0.333，P=0.024）。结论: JMJD2B和HIF-1α在儿童NHL组织中表达增高，二者在儿童NHL发生发展过程中可能起协同作用；JMJD2B可作为儿童NHL辅助诊断、评估病情、指导治疗、评估预后的新指标。.

Keywords: Child; Clinicopathological characteristic; Hypoxia-inducible factor-1α; Jumonji domain-containing protein 2B; Non-Hodgkin's lymphoma; Prognosis.

Publication types

  • English Abstract

MeSH terms

  • Child
  • Humans
  • Hypoxia
  • Hypoxia-Inducible Factor 1, alpha Subunit*
  • Lymphoma, Non-Hodgkin*
  • Prognosis

Substances

  • Hypoxia-Inducible Factor 1, alpha Subunit