Hepatitis B serological patterns of asymptomatic carriers in an endemic region and evaluation of blood plasma as a source of hepatitis B vaccine

C F Yoshida; I F Camargo; L A Mercadante; A M Gaspar; D F Gomes; H G Schatzmayr

doi:10.1016/0264-410x(86)90140-4

Hepatitis B serological patterns of asymptomatic carriers in an endemic region and evaluation of blood plasma as a source of hepatitis B vaccine

Vaccine. 1986 Dec;4(4):253-6. doi: 10.1016/0264-410x(86)90140-4.

Authors

C F Yoshida, I F Camargo, L A Mercadante, A M Gaspar, D F Gomes, H G Schatzmayr

PMID: 3799019
DOI: 10.1016/0264-410x(86)90140-4

Abstract

Hepatitis B serological studies were carried out in 251 asymptomatic carriers of HBsAg living in an endemic rural area of Cachoeiro do Itapemirim (545 km distant from Rio de Janeiro) in order to evaluate this population as a potential source of blood plasma for hepatitis B vaccine production. A pilot study on HBsAg purification from plasma was also performed to estimate antigen yield.

MeSH terms

Adolescent
Adult
Carrier State / blood
Carrier State / immunology*
Child
Hepatitis B / blood
Hepatitis B / immunology*
Hepatitis B / prevention & control
Hepatitis B Surface Antigens / isolation & purification
Humans
Middle Aged
Plasma / immunology
Viral Hepatitis Vaccines / isolation & purification*

Substances

Hepatitis B Surface Antigens
Viral Hepatitis Vaccines