The combined effects of overweight/obesity and dietary antioxidant quality score on hypertension in children and adolescents

Ying Zhong; Zhiqun Zhang; Youfang Hu

doi:10.1186/s12887-023-04397-0

The combined effects of overweight/obesity and dietary antioxidant quality score on hypertension in children and adolescents

BMC Pediatr. 2023 Nov 21;23(1):584. doi: 10.1186/s12887-023-04397-0.

Authors

Ying Zhong¹, Zhiqun Zhang², Youfang Hu³

Affiliations

¹ Department of Children's Health Care, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210036, China.
² Department of Neonatology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, 310000, China.
³ Department of Children's Health Care, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210036, China. 13182823903@126.com.

Abstract

Background: This study was to evaluate the combined effects of overweight/obesity and DAQS on the risk of hypertension in children and adolescents.

Methods: In this cross-sectional study, the data of 14,316 subjects were extracted from the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression analysis was used to explore the associations of obesity and DAQS with the risk of hypertension. The combined effect of overweight/obesity and DAQS on the risk of hypertension was evaluated.

Results: Body mass index (BMI)-for-age < 85^th percentile was associated with reduced risk of hypertension in children and adolescents [odds ratio (OR) = 0.48, 95% confidence interval (CI): 0.41-0.62]. No significant association between DAQS ≥ 3 and the risk of hypertension before and after the adjustment of confounders (P > 0.05). Subjects with BMI-for-age of < 85^th percentile and DAQS < 3 was associated with decreased risk of hypertension (OR = 0.53, 95%CI: 0.35-0.79). People with BMI-for-age of < 85^th percentile and DAQS ≥ 3 was correlated with decreased risk of hypertension (OR = 0.52, 95%CI: 0.36-0.74). Subgroup analysis revealed that in subjects aged ≥ 12 years, decreased risk of hypertension was observed in BMI-for-age < 85^th percentile and DAQS < 3 group (OR = 0.48, 95%CI: 0.31-0.73) as well as BMI-for-age < 85^th percentile and DAQS ≥ 3 group (OR = 0.47, 95%CI: 0.32-0.67). In boys, BMI-for-age < 85^th percentile and DAQS < 3 group (OR = 0.45, 95%CI: 0.25-0.81) as well as BMI-for-age < 85^th percentile and DAQS ≥ 3 group (OR = 0.40, 95%CI: 0.25-0.65) were correlated with decreased risk of hypertension.

Conclusion: Overweight/obesity and DAQS had combined effects on the risk of hypertension in children and adolescents, which implied that for children and adolescents with normal weight, to keep normal weight combined with high quality of diet might be recommended.

Keywords: Children and adolescents; Dietary antioxidant quality score; Hypertension; Obesity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Antioxidants
Body Mass Index
Child
Cross-Sectional Studies
Diet
Humans
Hypertension* / complications
Hypertension* / etiology
Male
Nutrition Surveys
Obesity / complications
Overweight* / complications

Substances

Antioxidants