Association between manganese exposure in heavy metals mixtures and the prevalence of sarcopenia in US adults from NHANES 2011-2018

Qiong Huang; Jinfa Wan; Wenbin Nan; Siqi Li; Baimei He; Zhenyu Peng

doi:10.1016/j.jhazmat.2023.133005

Association between manganese exposure in heavy metals mixtures and the prevalence of sarcopenia in US adults from NHANES 2011-2018

J Hazard Mater. 2024 Feb 15:464:133005. doi: 10.1016/j.jhazmat.2023.133005. Epub 2023 Nov 15.

Authors

Qiong Huang¹, Jinfa Wan², Wenbin Nan², Siqi Li³, Baimei He³, Zhenyu Peng⁴

Affiliations

¹ Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China; Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
² Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China; Emergency Medicine and Difficult Diseases Institute, Central South University, Changsha 410011, China.
³ Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
⁴ Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China; Emergency Medicine and Difficult Diseases Institute, Central South University, Changsha 410011, China. Electronic address: pengzhenyu1999@csu.edu.cn.

PMID: 37988867
DOI: 10.1016/j.jhazmat.2023.133005

Abstract

Environmental pollution is identified as an essential risk factor for sarcopenia. However, the effect of manganese (Mn) exposure on the prevalence of sarcopenia is not assessed. Our study investigated the correlation between blood Mn concentration and sarcopenia risk in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. Three statistical methods were used to assess these correlations. Mediation analysis was performed to explore the role of inflammation in Mn exposure-induced sarcopenia. Of the 4957 individuals enrolled in this study, 398 (8 %) were diagnosed with sarcopenia. We found a positive association between the log10 Mn concentration and the prevalence of sarcopenia in the logistic regression model. Moreover, heavy metals mixtures were positively correlated with the prevalence of sarcopenia, with Mn identified as the main contributor to this association in the weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models. Furthermore, inflammation mediated the relationship between Mn exposure and the prevalence of sarcopenia, explaining 7.29 % of the effect (odds ratio: 0.03, 0.19, P = 0.002). Thus, our study results revealed that excessive Mn exposure is a contributing factor for sarcopenia. More prospective studies are required to examine the association between Mn exposure and the prevalence of sarcopenia.

Keywords: Heavy metals; Inflammation; Manganese; NHANES; Sarcopenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bayes Theorem
Environmental Exposure / analysis
Humans
Inflammation
Manganese / analysis
Manganese / toxicity
Metals, Heavy* / analysis
Metals, Heavy* / toxicity
Nutrition Surveys
Prevalence
Sarcopenia* / chemically induced
Sarcopenia* / epidemiology

Substances

Manganese
Metals, Heavy