Apoptotic signaling: Beyond cell death

Maddalena Nano; Denise J Montell

doi:10.1016/j.semcdb.2023.11.002

Apoptotic signaling: Beyond cell death

Semin Cell Dev Biol. 2024 Mar 15:156:22-34. doi: 10.1016/j.semcdb.2023.11.002. Epub 2023 Nov 19.

Authors

Maddalena Nano¹, Denise J Montell²

Affiliations

¹ Molecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93106, USA; Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA. Electronic address: mnano@ucsb.edu.
² Molecular, Cellular, and Developmental Biology Department, University of California, Santa Barbara, CA 93106, USA; Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA. Electronic address: dmontell@ucsb.edu.

PMID: 37988794
DOI: 10.1016/j.semcdb.2023.11.002

Abstract

Apoptosis is the best described form of regulated cell death, and was, until relatively recently, considered irreversible once particular biochemical points-of-no-return were activated. In this manuscript, we examine the mechanisms cells use to escape from a self-amplifying death signaling module. We discuss the role of feedback, dynamics, propagation, and noise in apoptotic signaling. We conclude with a revised model for the role of apoptosis in animal development, homeostasis, and disease.

Keywords: Anastasis; Apoptosis; Caspase; Feedback in apoptosis; Regulated cell death.

Publication types

Review

MeSH terms

Animals
Apoptosis* / physiology
Cell Death
Signal Transduction*