Epidemiological and genetic characteristics of foot-and-mouth disease virus in China from 2010 to 2022

Xujiao Ren; Pengfei Li; Xiangmin Li; Ping Qian

doi:10.1016/j.virol.2023.109940

Epidemiological and genetic characteristics of foot-and-mouth disease virus in China from 2010 to 2022

Virology. 2024 Jan:589:109940. doi: 10.1016/j.virol.2023.109940. Epub 2023 Nov 11.

Authors

Xujiao Ren¹, Pengfei Li², Xiangmin Li², Ping Qian³

Affiliations

¹ National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, Hubei, China; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, 100101, China.
² National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, Hubei, China.
³ National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, Hubei, China. Electronic address: qianp@mail.hzau.edu.cn.

PMID: 37984153
DOI: 10.1016/j.virol.2023.109940

Abstract

Foot-and-mouth disease virus (FMDV) is a highly contagious picornavirus that can infect cloven-hoofed animals of significant agricultural importance. In China, foot-and-mouth disease (FMD) epidemics occur annually, resulting in localized outbreaks or sporadic epidemics that cause significant economic losses. This study summarized 123 cases of FMD reported in China between 2010 and 2022, using data from the official website of the Chinese Center for Animal Disease Control and Prevention. The epidemic situation and genetic characteristics of FMDV in China were studied through phylogenetic analysis, amino acid variation analysis of antigenic epitopes, and genetic recombination analysis. The findings provide important references for predicting the FMDV epidemic situation in China, developing vaccines, and effectively preventing and controlling FMD.

Keywords: Bioinformatic analysis; China; Foot-and-mouth disease; Molecular epidemiology; Prevalence.

MeSH terms

Animals
Disease Outbreaks
Epidemics*
Foot-and-Mouth Disease Virus*
Foot-and-Mouth Disease*
Phylogeny