68Ga-PSMA-11 PET/CT in Bilateral Clear Cell Renal Cell Carcinoma: an Intra-patient Comparison Between High and Low Grade Tumors

Luca Urso; Giovanni Christian Rocca; Grazia Maria Conti; Alessandro Colella; Alberto Nieri; Corrado Cittanti; Carmelo Ippolito; Mirco Bartolomei

doi:10.1007/s13139-023-00805-6

⁶⁸Ga-PSMA-11 PET/CT in Bilateral Clear Cell Renal Cell Carcinoma: an Intra-patient Comparison Between High and Low Grade Tumors

Nucl Med Mol Imaging. 2023 Dec;57(6):298-300. doi: 10.1007/s13139-023-00805-6. Epub 2023 Apr 24.

Authors

Luca Urso¹, Giovanni Christian Rocca², Grazia Maria Conti², Alessandro Colella², Alberto Nieri¹, Corrado Cittanti¹, Carmelo Ippolito², Mirco Bartolomei¹

Affiliations

¹ Nuclear Medicine Unit, Oncological Medical and Specialists Department, University Hospital of Ferrara, Ferrara, Italy.
² Urology Unit, Surgical Department, University Hospital of Ferrara, Ferrara, Italy.

PMID: 37982100
PMCID: PMC10654290 (available on 2024-12-01)
DOI: 10.1007/s13139-023-00805-6

Abstract

Recent studies have outlined the emerging role of ⁶⁸Ga-PSMA-11 PET/CT in the diagnostic algorithm of clear cell renal cell carcinoma (ccRCC). We report a unique intra-patient comparison of bilateral primary ccRCC imaged with ⁶⁸Ga-PSMA-11 PET/CT. Although both tumors resulted ⁶⁸Ga-PSMA-11 avid, we found a remarkable discrepancy in uptake intensity between the high grade and the low grade ccRCC. This case confirms previous evidence reporting that SUVmax on ⁶⁸Ga-PSMA-11 PET/CT could be used to discriminate aggressive high grade from more indolent low grade ccRCC, due to their different endothelial expression of PSMA.

Keywords: 68Ga-PSMA PET/CT; Clear cell renal cell carcinoma; PSMA PET; Renal cell carcinoma; ccRCC.