Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives

Gaoming Liu; Jun Wei; Wenfeng Xiao; Wenqing Xie; Qin Ru; Lin Chen; Yuxiang Wu; Ali Mobasheri; Yusheng Li

doi:10.1016/j.biopha.2023.115884

Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives

Biomed Pharmacother. 2023 Dec 31:169:115884. doi: 10.1016/j.biopha.2023.115884. Epub 2023 Nov 17.

Authors

Gaoming Liu¹, Jun Wei², Wenfeng Xiao³, Wenqing Xie¹, Qin Ru⁴, Lin Chen⁴, Yuxiang Wu⁵, Ali Mobasheri⁶, Yusheng Li⁷

Affiliations

¹ Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410011, China.
² Department of Clinical Medical School, Xinjiang Medical University, Urumqi 830054, China.
³ Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410011, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410011, China.
⁴ Department of Health and Physical Education, Jianghan University, Wuhan 430056, China.
⁵ Department of Health and Physical Education, Jianghan University, Wuhan 430056, China. Electronic address: yxwu@jhun.edu.cn.
⁶ Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Department of Orthopedics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, Belgium. Electronic address: ali.mobasheri@oulu.fi.
⁷ Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410011, China; Department of Clinical Medical School, Xinjiang Medical University, Urumqi 830054, China. Electronic address: liyusheng@csu.edu.cn.

PMID: 37981460
DOI: 10.1016/j.biopha.2023.115884

Abstract

Degenerative musculoskeletal disorders are a group of age-related diseases of the locomotive system that severely affects the patient's ability to work and cause adverse sequalae such as fractures and even death. The incidence and prevalence of degenerative musculoskeletal disorders is rising owing to the aging of the world's population. The Notch signaling pathway, which is expressed in almost all organ systems, extensively regulates cell proliferation and differentiation as well as cellular fate. Notch signaling shows increased activity in degenerative musculoskeletal disorders and retards the progression of degeneration to some extent. The review focuses on four major degenerative musculoskeletal disorders (osteoarthritis, intervertebral disc degeneration, osteoporosis, and sarcopenia) and summarizes the pathophysiological functions of Notch signaling in these disorders, especially its role in stem/progenitor cells in each disorder. Finally, a conclusion will be presented to explore the research and application of the perspectives on Notch signaling in degenerative musculoskeletal disorders.

Keywords: Degenerative musculoskeletal disorders; Intervertebral disc degeneration; Notch signaling pathway; Osteoarthritis; Osteoporosis; Sarcopenia; Stem/progenitor cells.

Publication types

Review

MeSH terms

Aging
Humans
Intervertebral Disc Degeneration* / metabolism
Osteoarthritis*
Osteoporosis*
Signal Transduction / physiology