New insights into glycogen synthase kinase-3: A common target for neurodegenerative diseases

Chengfeng Wang; Yu Cui; Tong Xu; Yu Zhou; Rong Yang; Ting Wang

doi:10.1016/j.bcp.2023.115923

New insights into glycogen synthase kinase-3: A common target for neurodegenerative diseases

Biochem Pharmacol. 2023 Dec:218:115923. doi: 10.1016/j.bcp.2023.115923. Epub 2023 Nov 18.

Authors

Chengfeng Wang¹, Yu Cui², Tong Xu³, Yu Zhou⁴, Rong Yang⁵, Ting Wang⁶

Affiliations

¹ Department of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong 266071, China.
² Department of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.
³ Department of Otorhinolaryngology Head and Neck, The Affiliated Qingdao Third People's Hospital of Qingdao University, Qingdao, Shandong 266021, China.
⁴ Department of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China; Institute of Brain Sciences and Related Disorders, Qingdao University, Qingdao, Shandong 266071, China; Department of Otorhinolaryngology Head and Neck, The Affiliated Qingdao Third People's Hospital of Qingdao University, Qingdao, Shandong 266021, China; Department of Health and Life Science, University of Health and Rehabilitation Sciences, Qingdao, Shandong 266000, China. Electronic address: yuzhou@qdu.edu.cn.
⁵ Department of Otorhinolaryngology Head and Neck, The Affiliated Qingdao Third People's Hospital of Qingdao University, Qingdao, Shandong 266021, China. Electronic address: jhtyr@sina.com.
⁶ Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China. Electronic address: tingwang@qdu.edu.cn.

PMID: 37981175
DOI: 10.1016/j.bcp.2023.115923

Abstract

Glycogen synthase kinase 3 (GSK-3) is a highly conserved protein serine/threonine kinase that plays a central role in a wide variety of cellular processes to coordinate catabolic and anabolic pathways and regulate cell growth and fate. There is increasing evidence showing that abnormal glycogen synthase kinase 3 (GSK-3) is associated with the pathogenesis and progression of many disorders, such as cancer, diabetes, psychiatric diseases, and neurodegenerative diseases. In this review, we summarize recent findings about the regulatory role of GSK-3 in the occurrence and development of multiple neurodegenerative diseases, mainly focusing on Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The aim of this study is to provide new insight into the shared working mechanism of GSK-3 as a therapeutic target of multiple neurodegenerative diseases.

Keywords: GSK-3; GSK-3 inhibitors; Neurodegeneration; Neuroprotection; Phosphorylation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease*
Diabetes Mellitus* / drug therapy
Glycogen Synthase Kinase 3
Glycogen Synthase Kinase 3 beta
Humans
Neurodegenerative Diseases* / drug therapy
Neurodegenerative Diseases* / metabolism
Parkinson Disease*

Substances

Glycogen Synthase Kinase 3
Glycogen Synthase Kinase 3 beta