Mechanism and treatment of olfactory dysfunction caused by coronavirus disease 2019

J Transl Med. 2023 Nov 17;21(1):829. doi: 10.1186/s12967-023-04719-x.

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the start of the pandemic, olfactory dysfunction (OD) has been reported as a common symptom of COVID-19. In some asymptomatic carriers, OD is often the first and even the only symptom. At the same time, persistent OD is also a long-term sequela seen after COVID-19 that can have a serious impact on the quality of life of patients. However, the pathogenesis of post-COVID-19 OD is still unclear, and there is no specific treatment for its patients. The aim of this paper was to review the research on OD caused by SARS-CoV-2 infection and to summarize the mechanism of action, the pathogenesis, and current treatments.

Keywords: COVID-19; Olfaction; Olfactory dysfunction; SARS-CoV-2.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19* / complications
  • Humans
  • Olfaction Disorders* / complications
  • Olfaction Disorders* / therapy
  • Quality of Life
  • SARS-CoV-2
  • Smell