Cytospotones A-D, four new polyketones from the endophytic fungus Cytospora sp. A879

Weipeng Ma; Zhishen Shao; Yuchan Chen; Saini Li; Hongxin Liu; Weimin Zhang; Xiaoxia Gao

doi:10.1016/j.fitote.2023.105751

Cytospotones A-D, four new polyketones from the endophytic fungus Cytospora sp. A879

Fitoterapia. 2024 Mar:173:105751. doi: 10.1016/j.fitote.2023.105751. Epub 2023 Nov 17.

Authors

Weipeng Ma¹, Zhishen Shao¹, Yuchan Chen², Saini Li², Hongxin Liu³, Weimin Zhang⁴, Xiaoxia Gao⁵

Affiliations

¹ School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China,; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
² State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
³ State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China. Electronic address: liuhx@gdim.cn.
⁴ State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China. Electronic address: wmzhang@gdim.cn.
⁵ School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China,. Electronic address: gaoxxia91@163.com.

PMID: 37977303
DOI: 10.1016/j.fitote.2023.105751

Abstract

Three new α-pyrone derivatives cytospotones A-C (1-3) and a new cyclohexenone derivative cytospotone D (4) together with four known α-pyrones were isolated from the endophytic fungus Cytospora sp. A879 of Pogostemon cablin (Blanco) Benth. The structures of 1-4 were elucidated primarily by spectroscopic methods (1D, 2D NMR and HRESIMS), ECD spectra analyses, and ECD calculations. Furthermore, the four new compounds (1-4) were evaluated for their anti-inflammatory and α-glucosidase inhibitory activities. The results showed that compound 1 had moderate inhibitory effect on LPS-induced NO production in RAW 264.7 macrophages.

Keywords: Anti-inflammatory activity; Cytospora sp.; Endophytic fungus; Pogostemon cablin (Blanco) Benth; α-Glucosidase inhibitory activity; α-Pyrone.

MeSH terms

Ascomycota* / chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Pogostemon*
Pyrones

Substances

Pyrones