Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn's Disease of the Pouch

Maia Kayal; Parakkal Deepak; Poonam Beniwal-Patel; Laura Raffals; Marla Dubinsky; Shannon Chang; Peter D R Higgins; Yue Jiang; Raymond K Cross; Millie D Long; Hans H Herfarth; Edward L Barnes

doi:10.14309/ajg.0000000000002599

Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn's Disease of the Pouch

Am J Gastroenterol. 2024 Feb 16. doi: 10.14309/ajg.0000000000002599. Online ahead of print.

Authors

Maia Kayal¹, Parakkal Deepak², Poonam Beniwal-Patel³, Laura Raffals⁴, Marla Dubinsky⁵, Shannon Chang⁶, Peter D R Higgins⁷, Yue Jiang⁸, Raymond K Cross⁹, Millie D Long¹⁰, Hans H Herfarth¹⁰, Edward L Barnes¹⁰

Affiliations

¹ Division of Gastroenterology, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
² Division of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
³ Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
⁴ Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
⁵ Division of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
⁶ Division of Gastroenterology and Hepatology, NYU Langone Health, New York, New York, USA.
⁷ Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA.
⁸ Trinity College of Arts and Sciences, Duke University, Durham, North Carolina, USA.
⁹ Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
¹⁰ Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, USA.

PMID: 37975591
DOI: 10.14309/ajg.0000000000002599

Abstract

Introduction: There is a paucity of data on the real-world effectiveness of therapies in patients with Crohn's disease of the pouch.

Methods: This was a prospective multicenter study evaluating the primary outcome of remission at 12 months of therapy for Crohn's disease of the pouch.

Results: One hundred thirty-four patients were enrolled. Among the 77 patients with symptoms at baseline, 35 (46.7%) achieved remission at 12 months. Of them, 12 (34.3%) changed therapy. There was no significant association between therapy patterns and remission status.

Discussion: Approximately 50% with symptoms at enrollment achieved clinical remission at 12 months, most of whom did so without a change in therapy.