Potential Microfluidic Devices for COVID-19 Antibody Detection at Point-of-Care (POC): A Review

Muhammad Tayyab; Muhammad Ahsan Sami; Hassan Raji; Srinivas Mushnoori; Mehdi Javanmard

doi:10.1109/JSEN.2020.3034892

Potential Microfluidic Devices for COVID-19 Antibody Detection at Point-of-Care (POC): A Review

IEEE Sens J. 2020 Oct 30;21(4):4007-4017. doi: 10.1109/JSEN.2020.3034892. eCollection 2021 Feb 15.

Authors

Muhammad Tayyab¹, Muhammad Ahsan Sami¹, Hassan Raji¹, Srinivas Mushnoori², Mehdi Javanmard¹

Affiliations

¹ Department of Electrical and Computer EngineeringRutgers University Piscataway NJ 08854 USA.
² Department of Chemical and Biochemical EngineeringRutgers University Piscataway NJ 08854 USA.

Abstract

COVID-19 has been declared a global pandemic which has brought the world economy and the society to a standstill. The current emphasis of testing is on detection of genetic material of SARS-CoV-2. Such tests are useful for assessing the current state of a subject: Infected or not infected. In addition to such tests, antibody testing is necessary to stratify the population into three groups: never exposed, infected, and immune. Such a stratification is necessary for safely reopening the society and remobilizing the economy. The aim of this review article is to inform the audience of the current diagnostic and surveillance technologies that are being employed for the detection of SARS-CoV-2 antibodies along with their shortcomings, and to highlight microfluidic sensors and devices that show promise of being commercialized for detection and quantification of SARS-CoV-2 antibodies in low-resource and Point-of-Care (POC) settings.

Keywords: Antibody; biosensors; chemical and biological sensors; enzyme linked immunosorbent assay (ELISA); protein.

Grants and funding

This work was supported by the National Science Foundation under Grant 1711165.