Early intervention of extracorporeal photopheresis for advancing/progressing cutaneous T-cell lymphoma

Abstract

Patients with cutaneous T-cell lymphoma with progressive disease typically undergo a series of skin-directed and systemic therapy regimens during cycles of response and relapse. Extracorporeal photopheresis (ECP) is an effective and safe systemic treatment option, often reserved for later stages of disease and typically employed after failure of several other therapies. ECP has benefits in response rate, time to next treatment, and tolerability that may support its use earlier in the treatment cycle for advancing/progressing disease.

Keywords: Sézary syndrome; cutaneous T-cell lymphoma; histone deacetylase inhibitors; interferons; mycosis fungoides; phototherapy; steroids.