PKCδ regulates the vascular biology in diabetic atherosclerosis

Peiliang Qin; Changhuai He; Pin Ye; Qin Li; Chuanqi Cai; Yiqing Li

doi:10.1186/s12964-023-01361-4

PKCδ regulates the vascular biology in diabetic atherosclerosis

Cell Commun Signal. 2023 Nov 16;21(1):330. doi: 10.1186/s12964-023-01361-4.

Authors

Peiliang Qin¹, Changhuai He¹, Pin Ye¹, Qin Li¹, Chuanqi Cai², Yiqing Li³

Affiliations

¹ Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
² Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. chuanqicai@hust.edu.cn.
³ Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. yiqingli_uh@126.com.

Abstract

Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)-protein kinase C (PKC) pathway plays an important role in atherosclerosis. PKCs can be divided into three subgroups: conventional PKCs (cPKCs), novel PKCs (nPKCs), and atypical PKCs (aPKCs). The aim of this review is to provide a comprehensive overview of the role of the PKCδ pathway, an isoform of nPKC, in regulating the function of endothelial cells, vascular smooth muscle cells, and macrophages in diabetic atherosclerosis. In addition, potential therapeutic targets regarding the PKCδ pathway are summarized. Video Abstract.

Keywords: Diabetic atherosclerosis; PKCδ pathway; Vascular biology; Vascular remodeling.

Publication types

Video-Audio Media
Review
Research Support, Non-U.S. Gov't

MeSH terms

Biology
Diabetes Mellitus*
Endothelial Cells* / metabolism
Humans
Protein Isoforms
Protein Kinase C / metabolism

Substances

Protein Kinase C
Protein Isoforms