SMPDL3A links cholesterol metabolism to the cGAS-STING pathway

Heegwon Shin; Hachung Chung

doi:10.1016/j.immuni.2023.10.015

SMPDL3A links cholesterol metabolism to the cGAS-STING pathway

Immunity. 2023 Nov 14;56(11):2459-2461. doi: 10.1016/j.immuni.2023.10.015.

Authors

Heegwon Shin¹, Hachung Chung²

Affiliations

¹ Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
² Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: hc3070@cumc.columbia.edu.

Abstract

Liver X receptor (LXR), well known for its role in cholesterol metabolism, also has anti-inflammatory properties. In this issue of Immunity, Hou et al. demonstrate that LXR signaling induces SMPDL3A, a cGAMP-degrading enzyme that restricts cGAS-cGAMP-STING innate immune signaling, providing a mechanistic link between lipid metabolism and inflammation.

MeSH terms

Cholesterol
Humans
Immunity, Innate
Inflammation
Lipid Metabolism
Nucleotidyltransferases* / genetics
Nucleotidyltransferases* / metabolism
Signal Transduction*

Substances

Nucleotidyltransferases
Cholesterol

Grants and funding

R01 NS127802/NS/NINDS NIH HHS/United States