Breathing cluster in complex neuron-astrocyte networks

Abstract

Brain activities are featured by spatially distributed neural clusters of coherent firings and a spontaneous slow switching of the clusters between the coherent and incoherent states. Evidences from recent in vivo experiments suggest that astrocytes, a type of glial cell regarded previously as providing only structural and metabolic supports to neurons, participate actively in brain functions by regulating the neural firing activities, yet the underlying mechanism remains unknown. Here, introducing astrocyte as a reservoir of the glutamate released from the neuron synapses, we propose the model of the complex neuron-astrocyte network, and investigate the roles of astrocytes in regulating the cluster synchronization behaviors of networked chaotic neurons. It is found that a specific set of neurons on the network are synchronized and form a cluster, while the remaining neurons are kept as desynchronized. Moreover, during the course of network evolution, the cluster is switching between the synchrony and asynchrony states in an intermittent fashion, henceforth the phenomenon of "breathing cluster." By the method of symmetry-based analysis, we conduct a theoretical investigation on the synchronizability of the cluster. It is revealed that the contents of the cluster are determined by the network symmetry, while the breathing of the cluster is attributed to the interplay between the neural network and the astrocyte. The phenomenon of breathing cluster is demonstrated in different network models, including networks with different sizes, nodal dynamics, and coupling functions. The findings shed light on the cellular mechanism of astrocytes in regulating neural activities and give insights into the state-switching of the neocortex.