Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that leads to cognitive impairment and memory loss. Emerging evidence suggests that autophagy plays an important role in the pathogenesis of AD through the regulation of amyloid-beta (Aβ) and tau metabolism, and that autophagy dysfunction exacerbates amyloidosis and tau pathology. Therefore, targeting autophagy may be an effective approach for the treatment of AD. Animal models are considered useful tools for investigating the pathogenic mechanisms and therapeutic strategies of diseases. This review aims to summarize the pathological alterations in autophagy in representative AD animal models and to present recent studies on newly discovered autophagy-stimulating interventions in animal AD models. Finally, the opportunities, difficulties, and future directions of autophagy targeting in AD therapy are discussed.
阿尔茨海默病（AD）是一种与年龄相关的神经退行性疾病，会导致认知障碍和记忆丧失。新的证据表明，自噬通过调节 Aβ 和tau代谢在AD发病机制中发挥重要作用，并且自噬功能障碍会加剧淀粉样变性和 tau 病理，因此靶向调控自噬可能是治疗AD的有效方法。动物模型被认为是研究疾病致病机制和治疗策略的实用工具，该综述旨在总结代表性的 AD动物模型中自噬的病理改变，并介绍新发现的自噬刺激干预措施应用于AD动物模型的最新研究，以及最后讨论了自噬靶向治疗AD面临的机遇、困难和未来方向。.
Keywords: Alzheimer’s disease; Animal models; Autophagy; Aβ metabolism; Tau pathology.