Diverse terpenoid glycosides with in vitro cytotoxicity from Glechoma longituba

Ming-Ming Yuan; Fang Xu; Yang-Bing Zheng; Lei-Gang Zhou; Yu Deng; Guo-Ping Zhou; Xi Wu; Teng-Fei Ji

doi:10.1016/j.phytochem.2023.113923

Diverse terpenoid glycosides with in vitro cytotoxicity from Glechoma longituba

Phytochemistry. 2024 Jan:217:113923. doi: 10.1016/j.phytochem.2023.113923. Epub 2023 Nov 12.

Authors

Ming-Ming Yuan¹, Fang Xu², Yang-Bing Zheng¹, Lei-Gang Zhou¹, Yu Deng¹, Guo-Ping Zhou¹, Xi Wu³, Teng-Fei Ji⁴

Affiliations

¹ Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Province Engineering Research Center of Drug and Medical Device Quality, Nanchang, 330029, China.
² State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
³ Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Province Engineering Research Center of Drug and Medical Device Quality, Nanchang, 330029, China. Electronic address: 13576090280@139.com.
⁴ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, 810008, China. Electronic address: jitf@imm.ac.cn.

PMID: 37963510
DOI: 10.1016/j.phytochem.2023.113923

Abstract

Terpenoids are the largest class of all known natural products, possessing structural diversity and numerous biological activities. Ten previously undescribed terpenoid glycosides, glechlongsides A-J (1-10), were isolated from the ethanol extract of the whole plant of Glechoma longituba, including diterpenoid glycoside and pentacyclic triterpenoid saponin. The structures of these compounds were characterized by extensive analysis of 1D and 2D NMR as well as HRESIMS spectra. In addition, glechlongsides F-I (6-9) exhibited weak cytotoxicity against human cancer cell lines BGC-823, Be1, HCT-8, A2780, and A549 with IC₅₀ values ranging from 3.77 to 30.95 μM, respectively.

Keywords: Cytotoxic activity; Diterpenoid glycoside; Glechoma longituba; Lamiaceae; Pentacyclic triterpenoid saponin; Terpenoid glycoside.

MeSH terms

Cell Line, Tumor
Female
Glycosides / chemistry
Glycosides / pharmacology
Humans
Lamiaceae* / chemistry
Molecular Structure
Ovarian Neoplasms*
Plant Extracts
Terpenes / pharmacology

Substances

Terpenes
Glycosides
Plant Extracts