Arthproliferins A-D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221

Bin Yang; Cuitian Li; Ying Chen; Yanchun He; Jianglian She; Xuefeng Zhou; Huangming Tao; Bo Peng

doi:10.3390/molecules28217246

Arthproliferins A-D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221

Molecules. 2023 Oct 24;28(21):7246. doi: 10.3390/molecules28217246.

Authors

Bin Yang¹, Cuitian Li², Ying Chen¹, Yanchun He¹, Jianglian She¹, Xuefeng Zhou¹, Huangming Tao³, Bo Peng⁴

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
² Marine Environmental Engineering Center, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510515, China.
³ School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
⁴ Institute for Environmental and Climate Research, Jinan University, Guangzhou 511443, China.

Abstract

Four new sesterterpenes, arthproliferins A-D (1-4), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. Some of the isolated compounds were evaluated for their cytotoxicity in vitro. The results revealed that terpestacin (6) exhibited significant activity with an IC₅₀ value of 20.3 μM, and compounds 2 and 5 were found to show weak inhibitory effects against U87MG-derived GSCs.

Keywords: Arthrinium sp.; cytotoxicity; mangrove-sediment-derived fungus; sesterterpenes.

MeSH terms

Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Sesterterpenes* / chemistry
Xylariales*

Substances

Sesterterpenes

Abstract

MeSH terms

Substances

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