Lower Urinary Tract Symptoms (LUTS) as a New Clinical Presentation of Histamine Intolerance: A Prevalence Study of Genetic Diamine Oxidase Deficiency

Jose Ponce Díaz-Reixa; Marcos Aller Rodríguez; Sara Martínez Breijo; Jorge Suanzes Hernández; Eva Ruiz Casares; Teresa Perucho Alcalde; Manuel Bohorquez Cruz; Teresa Mosquera Seoane; Jose M Sánchez Merino; Jacobo Freire Calvo; Paula Fernández Suárez; Venancio Chantada Abal

doi:10.3390/jcm12216870

Lower Urinary Tract Symptoms (LUTS) as a New Clinical Presentation of Histamine Intolerance: A Prevalence Study of Genetic Diamine Oxidase Deficiency

J Clin Med. 2023 Oct 31;12(21):6870. doi: 10.3390/jcm12216870.

Authors

Affiliations

¹ Urology Department, Complexo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain.
² Statistics Department, Complexo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain.
³ VIVO Laboratorio, Grupo Vivo, 28100 Alcobendas, Spain.
⁴ Department of Genetics, Faculty of Medicine, CEU-San Pablo University, 28668 Madrid, Spain.
⁵ Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain.
⁶ Radiodiagnostic Department, Complexo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain.

Abstract

Lower urinary tract symptoms (LUTS) are highly prevalent, and their treatment is mainly focused on the control of symptoms. Histamine intolerance (HIT) has been related to a variety of systemic symptoms. DAO deficiency has been identified as a significant factor contributing to histamine intolerance (HIT). Preclinical evidence indicates the involvement of histamine in the lower urinary tract. This study aimed to assess the prevalence of diamine oxidase deficiency (DAO) in a prospective cohort of 100 patients with at least moderate LUTS. A genetic study of four single nucleotide polymorphisms (SNPs) (c.-691G>T, c.47C>T, c.995C>T, and c.1990C>G) was performed. HIT was found in 85.9% of patients. The prevalence of at least one minor allele in the SNPs analyzed was 88%, without gender differences. Storage symptoms were more intense in the presence of HIT as well as asthenia and neurological and musculoskeletal symptoms. The presence of minor alleles of the AOC1 gene was associated with a higher intensity of symptoms. Minor alleles from c.-691G>T and c.47C>T SNPs were also associated with a greater severity of obstructive symptoms. Thirty-one percent of patients presented the four SNPS with at least one associated minor allele. The relationship between HIT and LUTS in a mixed population of men and women found in this study supports further investigations to define the pathophysiology of histamine in LUTS.

Keywords: DAO gene; diamine oxidase; histamine intolerance; lower urinary tract symptoms; single nucleotide polymorphisms.

Grants and funding

This work received external funding from Healthcare-AB Biotek HNH. The authors declare that no other funds, grants, or other forms of support were received during the preparation of this manuscript.