Glioblastoma and Solitary Brain Metastasis: Differentiation by Integrating Demographic-MRI and Deep-Learning Radiomics Signatures

Yuze Zhang; Hongbo Zhang; Hanwen Zhang; Ying Ouyang; Ruru Su; Wanqun Yang; Biao Huang

doi:10.1002/jmri.29123

Glioblastoma and Solitary Brain Metastasis: Differentiation by Integrating Demographic-MRI and Deep-Learning Radiomics Signatures

J Magn Reson Imaging. 2023 Nov 13. doi: 10.1002/jmri.29123. Online ahead of print.

Authors

Yuze Zhang^{1

2}, Hongbo Zhang^{1

2}, Hanwen Zhang^{1

2}, Ying Ouyang^{1

2}, Ruru Su^{1

2}, Wanqun Yang^{1

2}, Biao Huang^{1

2}

Affiliations

¹ Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
² Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

PMID: 37955154
DOI: 10.1002/jmri.29123

Abstract

Background: Studies have shown that deep-learning radiomics (DLR) could help differentiate glioblastoma (GBM) from solitary brain metastasis (SBM), but whether integrating demographic-MRI and DLR features can more accurately distinguish GBM from SBM remains uncertain.

Purpose: To construct and validate a demographic-MRI deep-learning radiomics nomogram (DDLRN) integrating demographic-MRI and DLR signatures to differentiate GBM from SBM preoperatively.

Study type: Retrospective.

Population: Two hundred and thirty-five patients with GBM (N = 115) or SBM (N = 120), randomly divided into a training cohort (90 GBM and 98 SBM) and a validation cohort (25 GBM and 22 SBM).

Field strength/sequence: Axial T2-weighted fast spin-echo sequence (T2WI), T2-weighted fluid-attenuated inversion recovery sequence (T2-FLAIR), and contrast-enhanced T1-weighted spin-echo sequence (CE-T1WI) using 1.5-T and 3.0-T scanners.

Assessment: The demographic-MRI signature was constructed with seven imaging features ("pool sign," "irregular ring sign," "regular ring sign," "intratumoral vessel sign," the ratio of the area of peritumoral edema to the enhanced tumor, the ratio of the lesion area on T2-FLAIR to CE-T1WI, and the tumor location) and demographic factors (age and sex). Based on multiparametric MRI, radiomics and deep-learning (DL) models, DLR signature, and DDLRN were developed and validated.

Statistical tests: The Mann-Whitney U test, Pearson test, least absolute shrinkage and selection operator, and support vector machine algorithm were applied for feature selection and construction of radiomics and DL models.

Results: DDLRN showed the best performance in differentiating GBM from SBM with area under the curves (AUCs) of 0.999 and 0.947 in the training and validation cohorts, respectively. Additionally, the DLR signature (AUC = 0.938) outperformed the radiomics and DL models, and the demographic-MRI signature (AUC = 0.775) was comparable to the T2-FLAIR radiomics and DL models in the validation cohort (AUC = 0.762 and 0.749, respectively).

Data conclusion: DDLRN integrating demographic-MRI and DLR signatures showed excellent performance in differentiating GBM from SBM.

Level of evidence: 3 TECHNICAL EFFICACY: Stage 2.

Keywords: deep-learning; glioblastoma; multiparametric; radiographic features; radiomics; solitary brain metastasis.

Abstract

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