Patient-reported swelling in arthralgia patients at risk for rheumatoid arthritis: is it of value?

Anna M P Boeren; Sarah J H Khidir; Pascal H P de Jong; Annette H M van der Helm-van Mil; Elise van Mulligen

doi:10.1093/rheumatology/kead606

Patient-reported swelling in arthralgia patients at risk for rheumatoid arthritis: is it of value?

Rheumatology (Oxford). 2023 Nov 11:kead606. doi: 10.1093/rheumatology/kead606. Online ahead of print.

Authors

Anna M P Boeren^{1

2}, Sarah J H Khidir², Pascal H P de Jong¹, Annette H M van der Helm-van Mil^{1

2}, Elise van Mulligen^{1

2}

Affiliations

¹ Department of Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands.
² Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 37952171
DOI: 10.1093/rheumatology/kead606

Abstract

Objective: Patients with Clinically Suspect Arthralgia (CSA) are at risk for developing Rheumatoid Arthritis (RA). These patients often report joint swelling while this is not objectified by physical examination. To explore the value of patient-reported swelling in CSA, we aimed to determine its association with subclinical joint-inflammation on imaging and RA-development.

Methods: In two independent, similarly designed CSA-cohorts from the Netherlands, symptomatic patients at risk for RA were studied. At baseline, patients indicated whether they had experienced swelling in hand joints. Subclinical joint-inflammation was assessed with MRI or ultrasound (US). Patients were followed for inflammatory arthritis development.

Results: In total, 534 CSA-patients from two independent cohorts were studied, patient-reported swelling was present in 57% in cohort 1, and in 43% in cohort 2. In both cohorts patient-reported swelling was associated with subclinical joint-inflammation. Using MRI, it associated specifically with tenosynovitis (OR 3.7 (95%CI 2.0-6.9)) and when using US with synovitis (OR 2.3 (95%CI 1.04-5.3)). CSA-patients with self-reported swelling at baseline developed arthritis more often, with hazard ratios of 3.7 (95%CI 2.0-6.9) and 3.4 (95%CI 1.4-8.4) in cohort 1 and 2, respectively. This was independent of clinical predictors (e.g. morning stiffness), autoantibody-positivity and US-detected subclinical joint-inflammation. However, when corrected for MRI-detected subclinical joint-inflammation, self-reported swelling was no longer an independent predictor.

Conclusion: Patient-reported joint swelling in CSA relates to subclinical joint-inflammation and is an independent risk factor for RA-development, but it is less predictive than the presence of MRI-detected subclinical joint-inflammation.

Keywords: Clinically Suspect Arthralgia; Magnetic Resonance Imaging; Patient-reported joint swelling; Rheumatoid Arthritis; Ultrasound.

Grants and funding

714312/ERC_/European Research Council/International