Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis

J Alex Albright; Mary Lou; Elliott Rebello; Jonathan Ge; Edward J Testa; Alan H Daniels; Michel Arcand

doi:10.1186/s13047-023-00678-0

Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis

J Foot Ankle Res. 2023 Nov 11;16(1):76. doi: 10.1186/s13047-023-00678-0.

Authors

J Alex Albright¹, Mary Lou², Elliott Rebello², Jonathan Ge², Edward J Testa³, Alan H Daniels³, Michel Arcand³

Affiliations

¹ Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA. James_Albright@brown.edu.
² Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
³ Department of Orthopaedics, Brown University Warren Alpert Medical School, Providence, RI, 02912, USA.

Abstract

Background: Prescription of testosterone replacement therapy (TRT) has increased in the United States in recent years, and though anabolic steroids have been associated with tendon rupture, there is a paucity of literature evaluating the risk of Achilles tendon injury with TRT. This study aims to evaluate the associative relationship between consistent TRT, Achilles tendon injury, and subsequent surgery.

Methods: This is a one-to-one matched retrospective cohort study utilizing the PearlDiver database. Records were queried for patients aged 35-75 who were prescribed at least 3 consecutive months of TRT between January 1, 2010 and December 31, 2019. Achilles tendon injuries and subsequent surgeries were identified using ICD-9, ICD-10, and CPT billing codes. Multivariable logistic regression was used to compare odds of Achilles tendon injury, Achilles tendon surgery, and revision surgery, with a p-value < 0.05 representing statistical significance.

Results: A sample of 423,278 patients who filled a TRT prescription for a minimum of 3 consecutive months was analyzed. The 2-year incidence of Achilles tendon injury was 377.8 (95% CI, 364.8-391.0) per 100,000 person-years in the TRT cohort, compared to 245.8 (95% CI, 235.4-256.6) in the control (p < 0.001). The adjusted analysis demonstrated TRT to be associated with a significantly increased likelihood of being diagnosed with Achilles tendon injury (aOR = 1.24, 95% CI, 1.15-1.33, p < 0.001). Of those diagnosed with Achilles tendon injury, 287/3,198 (9.0%) of the TRT cohort subsequently underwent surgery for their injury, compared to 134/2,081 (6.4%) in the control cohort (aOR = 1.54, 95% CI, 1.19-1.99, p < 0.001).

Conclusions: There is a significant association between Achilles tendon injury and prescription TRT, with a concomitantly increased rate of undergoing surgical management. These results provide insight into the risk profile of TRT and further research into the science of tendon pathology in the setting of TRT is an area of continued interest.

Keywords: Achilles; Surgery; Tendinopathy; Tendon Injury; Testosterone.

MeSH terms

Achilles Tendon* / injuries
Achilles Tendon* / surgery
Ankle Injuries*
Humans
Retrospective Studies
Rupture
Tendon Injuries* / chemically induced
Tendon Injuries* / epidemiology
Tendon Injuries* / surgery
Testosterone / adverse effects

Substances

Testosterone