tRNA-derived small RNA dataset in multiple organs of intrauterine growth-restricted pig

Ma Jianfeng; Gan Mailin; Yang Yitang; Chen Lei; Zhao Ye; Niu Lili; Wang Yan; Zhang Shunhua; Wang Jingyong; Zhu Li; Shen Linyuan

doi:10.1038/s41597-023-02715-w

tRNA-derived small RNA dataset in multiple organs of intrauterine growth-restricted pig

Sci Data. 2023 Nov 10;10(1):793. doi: 10.1038/s41597-023-02715-w.

Authors

Ma Jianfeng^#^{1

2}, Gan Mailin^#^{1

2}, Yang Yitang^#^{1

2}, Chen Lei^{1

2}, Zhao Ye^{1

2}, Niu Lili^{1

2}, Wang Yan^{1

2}, Zhang Shunhua^{1

2}, Wang Jingyong³, Zhu Li^{4

5}, Shen Linyuan^{6

7}

Affiliations

¹ Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
² Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu, China.
³ Chongqing Academy of Animal Science, Chongqing, China.
⁴ Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China. zhuli@sicau.edu.cn.
⁵ Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu, China. zhuli@sicau.edu.cn.
⁶ Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China. shenlinyuan@sicau.edu.cn.
⁷ Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu, China. shenlinyuan@sicau.edu.cn.

^# Contributed equally.

Abstract

Intrauterine growth restriction (IUGR) impairs neonatal weight and causes multiple organ dysplasia. IUGR not only threatens human health but is also a significant constraint to the development of animal husbandry. However, the molecular mechanism underlying IUGR remains to be further elucidated. tRNA-derived small RNA (tsRNAs) is a regulative non-coding RNA, which has recently been reported to correlate with the onset and progression of several diseases. In this study, we investigated the tsRNAs expression profiles of IUGR pigs. A tsRNAs dataset for multiple organs in normal and IUGR pigs was generated, including muscle, liver, spleen and intestine. We further analyzed the characteristics of tsRNAs in different organs of pigs, and KEGG pathway analysis was performed to investigate possible pathways involved. This dataset will provide valuable information for further exploring the molecular mechanism of IUGR formation.

Publication types

Dataset

MeSH terms

Animals
Fetal Growth Retardation / genetics
Fetal Growth Retardation / metabolism
RNA*
RNA, Transfer*
Swine*

Substances

RNA
RNA, Transfer