Background and aim: The triglyceride and glucose (TyG) index, as a surrogate marker of insulin resistance, was related to increased mortality. Our study aimed to investigate the specific relationship between the TyG index and all-cause mortality among obese population.
Methods and results: 6731 participants with obesity were enrolled from the National Health and Nutrition Examination Survey (NHANES). The TyG index was calculated as log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. The baseline levels of TyG associated with the risk of all-cause and cardiovascular mortality were evaluated by Cox proportional hazards models. After a follow-up of 16.7 years, 693 all-cause death and 133 cardiovascular deaths occurred. Dose-response curve showed that the association of the risk of all-cause mortality was non-linear (p = 0.019) and the corresponding TyG index ranged 8.78 to 9.64 for the lowest risk. Compared with the reference quartile of 8.79-9.22, the multivariate-adjusted hazards ratios were 1.32 ((95% confidence interval 1.03-1.70; p = 0.030) in the lowest quartile for all-cause mortality, and 0.55 (0.32-0.93; p = 0.025) in the second quartile for cardiovascular mortality.
Conclusions: TyG index was associated with the risk of all-cause mortality in obese participants and the level associated with the lowest risk was 8.78-9.64.
Keywords: All-cause mortality; Cardiovascular mortality; Insulin resistance; Obesity; Triglyceride glucose index.
Copyright © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.