Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures

Bahaa Abu-Raya; Frederic Reicherz; Christina Michalski; Marina Viñeta Paramo; Abdelilah Majdoubi; Liam Golding; Madison Granoski; Aleksandra Stojic; David J Marchant; Pascal M Lavoie

doi:10.1093/jpids/piad099

Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures

J Pediatric Infect Dis Soc. 2023 Oct 28;12(10):piad099. doi: 10.1093/jpids/piad099.

Authors

Bahaa Abu-Raya^{1

2}, Frederic Reicherz^{1

2

3}, Christina Michalski^{1

2}, Marina Viñeta Paramo^{1

2}, Abdelilah Majdoubi^{1

2}, Liam Golding^{1

2}, Madison Granoski⁴, Aleksandra Stojic⁴, David J Marchant⁴, Pascal M Lavoie^{1

2}

Affiliations

¹ British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
² Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
³ Department of Pediatrics, Children's Hospital Datteln, University of Witten/Herdecke, Datteln, Germany.
⁴ Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

PMID: 37948599
DOI: 10.1093/jpids/piad099

Abstract

Studies have linked respiratory syncytial virus (RSV) antibody-mediated phagocytosis and complement deposition to severe RSV infection in humans. This study shows waning of these antibody functions in women of childbearing age in 2020-2021 during the implementation of COVID-19 mitigation measures, in absence of RSV circulation. These functions could be explored as correlates of protection against severe RSV disease.

Keywords: COVID-19; Fc-mediated function; RSV; RSV hiatus; immunity debt.

© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.