Types of DNA damage and research progress

Liu Nian; Li Xiaohua; Li Rongcheng; Liu Song-Bai

doi:10.1080/15257770.2023.2277194

Types of DNA damage and research progress

Nucleosides Nucleotides Nucleic Acids. 2023 Nov 10:1-21. doi: 10.1080/15257770.2023.2277194. Online ahead of print.

Authors

Liu Nian^{1

2}, Li Xiaohua³, Li Rongcheng^{1

2}, Liu Song-Bai^{1

2}

Affiliations

¹ School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, China.
² Suzhou Key Laboratory of Medical Biotechnology, Suzhou Vocational Health College, Suzhou, China.
³ Thyroid and breast surgery, Wuzhong People's Hospital of Suzhou City, Suzhou, China.

PMID: 37948546
DOI: 10.1080/15257770.2023.2277194

Abstract

DNA damage is a modification in the structure of DNA under the influence of endogenous or exogenous factors. DNA damage can cause different types of diseases and is closely related to genetic mutations, cancer, and aging. The cause of the corresponding reaction process is essential for the study of related cancers and other genetically related diseases. Therefore, it is essential to gain a deeper understanding of the various types of DNA damage. This paper provides a comprehensive review of recent advances in the types of DNA damage and associated reaction processes, including damage to DNA bases, nucleotides, and strands, as well as the biological implications of the damage.

Keywords: DNA base damage; DNA mutation; DNA nucleotide damage; DNA strand damage.

Publication types

Review