Aggregation-induced emission (AIE)-active metallacycles with near-infrared emission for photodynamic therapy

Qifei Shen; Kai Gao; Zhiqin Zhao; Anran Gao; Yanzi Xu; Heng Wang; Lingjie Meng; Mingming Zhang; Dongfeng Dang

doi:10.1039/d3cc04166b

Aggregation-induced emission (AIE)-active metallacycles with near-infrared emission for photodynamic therapy

Chem Commun (Camb). 2023 Nov 23;59(94):14021-14024. doi: 10.1039/d3cc04166b.

Authors

Qifei Shen¹, Kai Gao², Zhiqin Zhao¹, Anran Gao¹, Yanzi Xu¹, Heng Wang³, Lingjie Meng^{1

4}, Mingming Zhang², Dongfeng Dang¹

Affiliations

¹ School of Chemistry, Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China. dongfengdang@xjtu.edu.cn.
² State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
³ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.
⁴ Instrumental Analysis Center, Xi'an Jiao Tong University, Xi'an, 710049, P. R. China.

PMID: 37946537
DOI: 10.1039/d3cc04166b

Abstract

Multifunctional metallacycles with solid-state emission are highly important in cancer therapy. Here, an aggregation-induced emission (AIE)-active metallacycle of DTPABT-MC-R is developed with efficient emission in the NIR region in the solid state (PLQYs = 4.92%). DTPABT-MC-R-based nanoparticles also display excellent photo-stability, and impressive photosensitive characteristics (ROS efficiency = 10.74%), finally leading to applications in cellular imaging and photodynamic therapy (PDT).

MeSH terms

Dermatitis, Phototoxic*
Humans
Nanoparticles*
Neoplasms* / diagnostic imaging
Neoplasms* / drug therapy
Photochemotherapy* / methods
Photosensitizing Agents / pharmacology

Substances

Photosensitizing Agents